Word of the Day
LIEU (loo)
Place, stead
Common clues: Stead; In ____ of
Crossword puzzle frequency: 5 times a year
Frequency in English language: 38534 / 86800
In
1947 Gerhard Domagk received a gold medal in lieu of the
prize money.
In 1939, Domagk received the Nobel Prize in Medicine for this discovery, the first drug effective against bacterial infections. He was forced by the Nazi regime to refuse the prize, after the Nazi-critical Carl von Ossietzky had won the Nobel Peace Prize in 1935. Sulfonamides became a revolutionary weapon at the time, surpassing phage therapy, but were later replaced by penicillin, which showed both better effects and fewer side effects (sulfonamides can cause kidney stones and changes in bone marrow). Domagk's work on sulfonamides eventually led to the development of the antituberculosis drugs thiosemicarbazone and isoniazid, which helped to curb the epidemic of tuberculosis which swept Europe after World War II.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Gerhard Domagk".
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